Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.
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- NUMABE Atsushi
- Department of Clinical Laboratory Medicine and Institute of Medical Science, Dokkyo University School of Medicine
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- ARA Nusrat
- Department of Cardiology, Rawalpindi Medical School
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- HAKAMADA-TAGUCHI Rie
- Health Service Center, University of Tokyo
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- SUZUKI Noriko
- Department of Clinical Laboratory Medicine and Institute of Medical Science, Dokkyo University School of Medicine
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- HIRAWA Nobuhito
- Second Department of Medicine, Yokohama City University
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- KAWABATA Yukari
- Department of Medicine, University of Tokyo
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- NEGORO Toshiyuki
- Department of Medicine, University of Tokyo
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- NAGATA Taiji
- Department of Medicine, University of Tokyo
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- GOTO Atsuo
- Department of Medicine, University of Tokyo
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- TOYO-OKA Teruhiko
- Health Service Center, University of Tokyo
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- FUJITA Toshiro
- Department of Medicine, University of Tokyo
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- UEHARA Yoshio
- Health Service Center, University of Tokyo Department of Medicine, University of Tokyo
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Among the consequences of the increasing prolongation of lifespan is a worldwide increase in the number of cases of dementia or impaired cognition. In the present study, to test the hypothesis that mechanisms independent of high blood pressure are involved in maintaining cognitive function, we assessed the effects of long-term dilazep treatment on cognitive dysfunction in normotensive Dahl salt-sensitive (Dahl S) rats fed a low-salt diet, using the standard passive avoidance test. Normotensive Dahl S rats fed a 0.3% NaCl diet were treated for 6 months with low-dose dilazep (2.5μg/ml in drinking water) or high-dose dilazep (12.5μg/ml). Systolic blood pressure was within normotensive range throughout the study and did not differ among the experimental groups. The results of the passive avoidance test revealed that dilazep treatment attenuated the decline of latency time relative to that in the untreated control rats (control latency time, 235 s; low-dilazep group, 389 s; high-dilazep group, 397 s), suggesting that the cognitive function of normotensive Dahl S rats was improved by dilazep treatment. This improvement of cognition was associated with significant increases in the number of neuronal cells in the hippocampal region and with an increase in capillary length in dilazep-treated Dahl rats. In addition, the dilazep treatments significantly attenuated arteriolar injury of glomeruli in the kidney. These data suggest that dilazep treatment, through vascular and non-vascular effects, maintains the brain function in Dahl S rats susceptible to vascular injury and organ dysfunction. (Hypertens Res 2003; 26: 185-191)
収録刊行物
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- Hypertension Research
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Hypertension Research 26 (2), 185-191, 2003
日本高血圧学会
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詳細情報 詳細情報について
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- CRID
- 1390001204718754176
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- NII論文ID
- 130004437037
- 50000753376
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- NII書誌ID
- AA10847079
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- COI
- 1:CAS:528:DC%2BD3sXisVKhs7c%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 12627880
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可