緑膿菌に対するbiapenemのin vitro殺菌力評価

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  • Evaluation of in vitro bactericidal activity of biapenem against Pseudomonas aeruginosa

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The bactericidal activity of biapenem (BIPM) against Pseudomonas aeruginosa was compared with that of imipenem/cilastatin (IPM/CS), meropenem (MEPM) and ceftazidime (CAZ) in a short-term in vitro pharmacokinetic model simulating the typical plasma levels of these drugs in human. The short-term bactericidal activity of BIPM against P. aeruginosa was similar to that of IPM/CS. The initial bactericidal activity of BIPM against P. aeruginosa was stronger than those of MEPM or CAZ. The short-term bactericidal activity of BIPM and IPM/CS against P. aeruginosa was not affected by the inoculum size. The bactericidal activity against P. aeruginosa in a model simulating the plasma level after a drip infusion of BIPM (300mg/30min) in humans was equal to those of IPM/CS (500mg/30min) and MEPM (500mg/30min). These.results suggest that BIPM is useful for the treatment of infectious disease caused by P. aeruginosa.

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