書誌事項
- タイトル別名
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- Evaluation of in vitro bactericidal activity of biapenem against Pseudomonas aeruginosa
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The bactericidal activity of biapenem (BIPM) against Pseudomonas aeruginosa was compared with that of imipenem/cilastatin (IPM/CS), meropenem (MEPM) and ceftazidime (CAZ) in a short-term in vitro pharmacokinetic model simulating the typical plasma levels of these drugs in human. The short-term bactericidal activity of BIPM against P. aeruginosa was similar to that of IPM/CS. The initial bactericidal activity of BIPM against P. aeruginosa was stronger than those of MEPM or CAZ. The short-term bactericidal activity of BIPM and IPM/CS against P. aeruginosa was not affected by the inoculum size. The bactericidal activity against P. aeruginosa in a model simulating the plasma level after a drip infusion of BIPM (300mg/30min) in humans was equal to those of IPM/CS (500mg/30min) and MEPM (500mg/30min). These.results suggest that BIPM is useful for the treatment of infectious disease caused by P. aeruginosa.
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 51 (4), 173-178, 2003
公益社団法人 日本化学療法学会
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詳細情報
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- CRID
- 1390282681262777856
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- NII論文ID
- 130004102656
- 50000808587
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可