マウス上顎第一臼歯の癒合根成因に対する遺伝学的検討

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  • Genetic Study of the Fused upper Molar Roots in Inbred Mice

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We have recently reported that the EL (epilepsy-like disorder) mice have a high incidence of missing third molars and fused roots of the upper first molar. The purpose of this study was to determine whether the appearance of the fused upper molar roots is controlled by genetic factors. The genetic study was performed on genetic crosses of EL mice, which had fused roots, and DDY mice, which had normal roots. The frequency of the fused roots was 60% for the EL mice and there was no significant difference between the sexes. There were no observations of the fused roots in both DDY and F1 hybrids,9.1% of the F 2 mice had fused roots of the upper first molar. The incidence of the fused roots (mesio-buccal and lingual roots) with unilateral was 77.8% for the EL mice and was 100% for F2 mice.<BR>Based on the results of the incidence rates of the fused roots in both F 1 hybrids and F 2 intercross mice, it was suggested that the genetic factor as autosomal recessive inheritance affected the development of the fused upper molar roots in EL mice.

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