Genome-Wide Linkage Disequilibrium Mapping of Hypertension in Japan

DOI PubMed 4 Citations 58 References
  • WU Zhihong
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • NAKURA Jun
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • ABE Michiko
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • JIN Jing-Ji
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • YAMAMOTO Miyuki
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • CHEN Yusen
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • TABARA Yasuharu
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • YAMAMOTO Yoshikuni
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • IGASE Michiya
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • BO Xiao
    Department of Neurology, Xiang Ya School of Medicine, Central South University
  • KOHARA Katsuhiko
    Department of Geriatric Medicine, School of Medicine, Ehime University
  • MIKI Tetsuro
    Department of Geriatric Medicine, School of Medicine, Ehime University

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Abstract

Hypertension is a common, complex phenotype resulting from the interaction between genetic and environmental factors. To select candidate regions potentially responsible for hypertension, we are conducting a genome-wide linkage disequilibrium (LD) mapping of hypertension using dinucleotide repeat markers in 146 hypertensive and 136 normotensive subjects. Although the LD mapping is still underway, 19 alleles of 15 markers have already shown a nominally significant association (p <0.05), with odds ratios ranging from 0.08 to 5.12, suggesting the presence of many hypertension-related loci with weak effects in the human genome. These markers should be further assessed, adjusting for confounding factors and considering gene-gene and gene-environmental interactions in additional samples. In this report, we discuss our ongoing LD mapping project and describe the 15 markers thus far discovered. Among the 15 markers, D10S537 had a highly significant association with hypertension (p =5.3×10-5; OR=3.80; 95% CI=1.98-7.27; where OR indicates the odds ratio and 95% CI indicates the 95% confidence interval). Further analysis in a large Japanese population showed that D10S537 was significantly associated with hypertension (p =0.044; OR=1.27; 95% CI=1.01-1.59). D10S537 was more significantly associated with hypertension in subjects with normotriglyceridemia in our population (p =0.007; OR=1.47; 95% CI=1.11-1.95). (Hypertens Res 2003; 26: 533-540)

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