好酸球性腸炎の1例および本邦報告60例の文献的考察

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  • A CASE OF EOSINOPHILIC ENTERITIS AND REVIEWS OF JAPANESE LITERATURES

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A case of eosinophilic enteritis was experienced. The case which was 63 y. o. woman with chief complaints of abdominal pain and watery diarrea was admitted on 28th Sep. in 1988. Laboratory data on admission showed leukocytosis with remarkable eosinophilia. By gastrointestinal endoscopy edematous change of the mucosa was observed diffusely in the duodenal bulb and 2nd portion. Biopsy specimen from the duodenum revealed diffuse infiltration of eosinophils in the mucosal and submucosal layer. The case was diagnosed as eosinophilic enteritis and her clinical symptoms and eosinophilia were improved significantly with corticosteroid therapy. The patient had gastrointestinal endoscopy again on the 18th day after the beginning of corticosteroid therapy. No edematous change was found in the mucosa of the duodenum, and biopsy specimen showed no infiltration of eosinophils. We have shown the rapid effectiveness of corticosteroid therapy to eosinophilic enteritis not only in clinical symptoms and eosinophilia but also in histological findings. By reviewing the Japanese literatures on eosinophilic gastroenteritis, we have concluded that it would be better to add the "Transmural disease" to Klein's classification, as we reported.

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