背部痛・高アミラーゼ血症で入院し血糖低値を示した後，発症したＩＤＤＭの１例

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タイトル別名
  • A Case of Insulin-Dependent Diabetes Mellitus Developing after Elevation of Serum Amylase Level and Low Plasma Glucose Level.

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A 24-year-old male was admitted in June 1990 for treatment of fever. On admission, he did not have clinical signs of pancreatitis but elevated levels of serum amylase (568IU/l), urine amylase (5550 IU/l), elastase 1 (4800 ng/dl) and lipase (636 IU/l) indicated pancreatitis and approriate treatment was initiated. Serum glucose level was low, 65 and 56 mg/dl on days 2 and 3, respectively. On day 4, it increased suddenly, and insulin treatment was required. All pancreatic enzymes had returned to normal levels around 12 weeks after admission, and ICA/ICSA were negative at that time. The HLA type was DR4/9, the most common type in Japanese IDDM.<BR>In this case, IDDM developed after elevation of serum amylasemia and decrease in plasma glucose, indicating the possibility of simultaneous destruction of both endocrine and exocrine pancreatic functions in this case.<BR>Elevation of serum amylase is often seen in the initial phase of IDDM and has been considered to be closely connected with the causative mechanism of IDDM.<BR>This patient was a rare and informative case in whom the entire course of development of IDDM from its earliest stage could be observed during hospitalization.

収録刊行物

  • 糖尿病

    糖尿病 35 (2), 121-126, 1992

    一般社団法人 日本糖尿病学会

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