Spatiotemporal patterns of the <i><scp>H</scp>untingtin‐interacting protein 1‐related</i> gene in the mouse head
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- Tomoyuki Masuda
- Department of Histology and Neurobiology Dokkyo Medical University School of Medicine Tochigi Japan
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- Chie Sakuma
- Department of Anatomy Fukushima Medical University School of Medicine Fukushima Japan
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- Takayuki Ueno
- Department of Anatomy Fukushima Medical University School of Medicine Fukushima Japan
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- Yuriko Yamada
- Department of Anatomy Fukushima Medical University School of Medicine Fukushima Japan
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- Hideki Ohmomo
- Department of Histology and Neurobiology Dokkyo Medical University School of Medicine Tochigi Japan
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- Shuichi Ueda
- Department of Histology and Neurobiology Dokkyo Medical University School of Medicine Tochigi Japan
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- Toshiyuki Yamagishi
- Department of Anatomy, Graduate School of Medicine Osaka City University Osaka Japan
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- Hiroyuki Yaginuma
- Department of Anatomy Fukushima Medical University School of Medicine Fukushima Japan
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<jats:title>Abstract</jats:title><jats:p><jats:italic><jats:styled-content style="fixed-case">H</jats:styled-content>untingtin‐interacting protein 1‐related</jats:italic> (<jats:italic><jats:styled-content style="fixed-case">Hip1r</jats:styled-content></jats:italic>) was originally identified due to its homology to <jats:italic><jats:styled-content style="fixed-case">H</jats:styled-content>untingtin‐interacting protein 1</jats:italic>, which contributes to the development of Huntington's disease (<jats:styled-content style="fixed-case">HD</jats:styled-content>). We studied the expression of the mouse <jats:italic><jats:styled-content style="fixed-case">Hip1r</jats:styled-content></jats:italic> (<jats:italic><jats:styled-content style="fixed-case">mHip1r</jats:styled-content></jats:italic>) gene in the mouse head by <jats:italic>in situ</jats:italic> hybridization. In early embryogenesis at embryonic day (<jats:styled-content style="fixed-case">E</jats:styled-content>) 13, <jats:italic><jats:styled-content style="fixed-case">mHip1r</jats:styled-content></jats:italic> expression was especially prominent in the olfactory epithelium, cerebral cortex layer 1, cortical plate, and dentate gyrus. During later development from <jats:styled-content style="fixed-case">E15</jats:styled-content> to <jats:styled-content style="fixed-case">E17</jats:styled-content>, strong expression of <jats:italic><jats:styled-content style="fixed-case">mHip1r</jats:styled-content></jats:italic> transcripts continued to be observed in the olfactory epithelium, cortical plate, and dentate gyrus. Furthermore, not only the subplate and subventricular zone of the cortex, but also secretory glands, such as the nasal gland and the submandibular gland, were <jats:italic><jats:styled-content style="fixed-case">mHip1r</jats:styled-content></jats:italic>‐positive. Other positive tissues included the retinal ganglion cells, vomeronasal organ, trigeminal ganglion, and the developing molar tooth. In the adult mouse brain, similar expression patterns were observed in the cerebral cortex layers and other brain regions except the cerebellum. Additionally, by using an antibody against <jats:styled-content style="fixed-case">mHip1r</jats:styled-content>, we confirmed these expression patterns at the protein level. Specific expression of mHip1r in the embryonic brain and secretory glands suggests a possible role for <jats:styled-content style="fixed-case">Hip1r</jats:styled-content> in normal development and in the pathology of <jats:styled-content style="fixed-case">HD</jats:styled-content>.</jats:p>
収録刊行物
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- Congenital Anomalies
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Congenital Anomalies 53 (4), 141-148, 2013-12
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360003446370436864
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- NII論文ID
- 50008967607
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- ISSN
- 17414520
- 09143505
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