Proliferation and differentiation characteristics of neural stem cells during course of cerebral cortical histogenesis

• Takayuki Mitsuhashi

  Department of Pediatrics School of Medicine Keio University Tokyo Japan

• Takao Takahashi

  Department of Pediatrics School of Medicine Keio University Tokyo Japan

抄録

Recent advancements in the research field of stem cell biology have enabled the realization of regenerative medicine in various systems of the body, including the central nervous system. However, fundamental knowledge regarding how neural stem cells divide and generate young neurons in mammals, especially in vivo , is still inadequate. In this article, we shall summarize the concept of cell cycle/division of neural stem cells that generate projection neurons in the murine cerebral cortex. We shall also review the molecular mechanisms that modulate the critical parameters related to the cell cycle regulatory mechanisms, with special reference to the cell cycle regulatory protein p27 Kip1 , an inhibitor of progression of the cell cycle at the <jats:styled-content style="fixed-case">G 1 phase. A better understanding of the mechanisms controlling cell cycle progression is expected to contribute to the development of novel strategies to increase the efficiency of neural cell/tissue production, both in vivo and in vitro .

収録刊行物

• Congenital Anomalies

  Congenital Anomalies 56 (1), 6-11, 2016-01

  Wiley

キーワード

• Developmental Biology
• Embryology
• General Medicine
• Pediatrics, Perinatology and Child Health

詳細情報

• CRID: 1360847871300733696
• NII論文ID: 50009864892
• DOI: 10.1111/cga.12117
• ISSN: 17414520
• ISSN: 09143505
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcga.12117
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/cga.12117
• Web Site: https://search.jamas.or.jp/link/ui/2016359947
• データソース種別:
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  • CiNii Articles
  • KAKEN