Molecular mechanisms underlying the models of neurodevelopmental disorders in maternal immune activation relevant to the placenta
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- Tsuyoshi Tsukada
- Department of Anatomy Kanazawa Medical University Uchinada Japan
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- Hiroki Shimada
- Department of Anatomy Kanazawa Medical University Uchinada Japan
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- Hiromi Sakata‐Haga
- Department of Anatomy Kanazawa Medical University Uchinada Japan
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- Hideaki Iizuka
- Department of Neurosurgery Kanazawa Medical University Uchinada Japan
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- Toshihisa Hatta
- Department of Anatomy Kanazawa Medical University Uchinada Japan
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<jats:p>The rapid rise in the prevalence of autism spectrum disorders (ASD) and other psychiatric disorders displaying similar traits has increased the need to elucidate their molecular mechanisms. Epidemiological studies have shown that maternal infection during mid‐pregnancy is associated with increased risk of neurodevelopmental disorders such as ASD in offspring. Using maternal infection models, researchers have gathered evidence relevant to such disorders. A comprehensive summary of the changes in the brain structure, function, and behavior in offspring induced by maternal immune activation (MIA) has been reported. However, the molecular mechanisms underlying the association between MIA and improper brain development, which ultimately lead to neurodevelopmental disorders, have not been fully reviewed. This paper summarizes the currently known molecular mechanisms associated with the MIA model, with a special focus on the role of the placenta in fetal brain development.</jats:p>
収録刊行物
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- Congenital Anomalies
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Congenital Anomalies 59 (3), 81-87, 2019-01-17
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360847871301026560
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- NII論文ID
- 50014236529
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- ISSN
- 17414520
- 09143505
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- Web Site
- https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcga.12323
- https://onlinelibrary.wiley.com/doi/pdf/10.1111/cga.12323
- https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cga.12323
- https://onlinelibrary.wiley.com/doi/am-pdf/10.1111%2Fcga.12323
- https://search.jamas.or.jp/link/ui/2020232528
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