Anti-thyroid peroxidase antibody and thyroid cysts among the general Japanese population: a cross-sectional study

• Shimizu, Yuji

• Nabeshima-Kimura, Yuko

• Kawashiri, Shin-Ya

• Noguchi, Yuko

• Nagata, Yasuhiro

• Maeda, Takahiro

• Hayashida, Naomi

Abstract

BACKGROUND: Anti-thyroid peroxidase antibody (TPO-Ab) has been shown to cause autoimmune thyroiditis by inducing a deleterious influence on thyroid hormone synthesis. Further, thyroglobulin, which has an important role in thyroid hormone synthesis, is reported to be high in the fluid from thyroid cysts. Therefore, TPO-Ab could be associated with the presence of thyroid cyst, partly by affecting the activity of thyroid hormone synthesis. METHODS: To investigate the association between TPO-Ab and thyroid cysts, we conducted a cross-sectional study of 1432 Japanese with normal thyroid function [i.e., normal range of free triiodothyronine (free T3) and free thyroxine (free T4)] between the ages of 40 and 74?years, who participated in an annual health check-up. RESULTS: In men, the statistical power did not reach a statistical significance value. Additionally, subjects with TPO-Ab showed lower odds ratios (ORs) of thyroid cysts than those without TPO-Ab. In women, subjects with TPO-Ab showed significantly lower ORs of thyroid cysts than those without TPO-Ab. The fully adjusted ORs were 0.68 (0.40, 1.18) for men and 0.40 (0.27, 0.60) for women. When evaluating the association between logarithmic values of TPO-Ab titer and thyroid cysts in both men and women, a notable inverse correlation was observed. The fully adjusted ORs were 0.68 (0.50, 0.92) for men and 0.68 (0.57, 0.81) for women. CONCLUSION: TPO-Ab titer revealed to be inversely associated with thyroid cysts among Japanese with normal thyroid function. The presence of a thyroid cyst could indicate a lower risk of having TPO-Ab among the general population with normal thyroid function.

Environmental health and preventive medicine, 25(1), art.no.7; 2020

Journal

• Environmental Health and Preventive Medicine

  Environmental Health and Preventive Medicine 25 (1), 7-, 2020-02-21

  BioMed Central Ltd.

Keywords

• Anti-thyroid peroxidase antibody
• Cross-sectional study
• Normal thyroid function
• Thyroid cysts
• Thyroid hormone

Details

• CRID: 1050287297264000128
• NII Article ID: 50014371181
• ISSN: 1342078X
• ISSN: 13474715
• DOI: 10.1186/s12199-020-00844-x
• HANDLE: 10069/39702
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/533
• Web Site: http://link.springer.com/content/pdf/10.1186/s12199-020-00844-x.pdf
• Web Site: http://link.springer.com/article/10.1186/s12199-020-00844-x/fulltext.html
• Web Site: https://search.jamas.or.jp/link/ui/2021000046
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN