Transformation of Human Leukocytes by Cocultivation with an Adult T Cell Leukemia Virus Producer Cell Line

DOI Web Site 被引用文献22件
  • Naoki Yamamoto
    nstitute for Virus Research, Kyoto University, Kyoto 606, Japan
  • Morihisa Okada
    nstitute for Virus Research, Kyoto University, Kyoto 606, Japan
  • Yoshio Koyanagi
    nstitute for Virus Research, Kyoto University, Kyoto 606, Japan
  • Mari Kannagi
    nstitute for Virus Research, Kyoto University, Kyoto 606, Japan
  • Yorio Hinuma
    nstitute for Virus Research, Kyoto University, Kyoto 606, Japan

抄録

<jats:p>The transmission of adult T cell leukemia virus, a human retrovirus, into fresh leukocytes from normal humans was examined. One of three virus-carrying cell lines, tested after being subjected to lethal x-irradiation, consistently transformed leukocytes from adult peripheral blood and umbilical cord blood. All the transformed cell lines expressed adult T cell leukemia virus-associated antigen, but transformed lines originating from adult and umbilical cord blood exhibited T cell and non-T, non-B cell surface natures, respectively. Efforts to transform human leukocytes with cell-free virus were unsuccessful.</jats:p>

収録刊行物

  • Science

    Science 217 (4561), 737-739, 1982-08-20

    American Association for the Advancement of Science (AAAS)

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