Osteolathyrismラットの抜歯創の破骨細胞性骨吸収に関する形態学的研究

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  • Morphological studies on osteoclastic bone resorption in extraction wound of lathyric rat

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The present studies were performed to investigate the process of osteoclastic bone resorption in an extraction wound and to clarify the difference between normal and lathyric condition.<BR>316 Wistar rats of 90-110g body weight were used. The Experimental rats were intraperitoneally given a 2.5% aqueous solution of aminoacetonitrile (AAN) in a dosage of 200mg/kg daily. On the 10 th day of AAN administration, the left upper first molar of each rat was extracted and AAN administration was continued. The rats were sacrificed at intervals from 0 day to 5 days after extraction. Control rats were sacrificed at same intervals after extraction. The maxillary bone including the extraction wound was examined histologically, histometrically, histochemically and ultrastructurally.<BR>A large number of osteoclasts appeared in the extraction wound and increased rapidly by 3 days after extraction in the control rats and 2.5 days in the lathyric rats.<BR>In lathyric rats, the osteoclasts were more numerous and increased more rapidly when compared with control rats. Histometrically, there was no significant difference in the amount of bone loss between control and lathyric rats. Histochemical examination revealed that the surrounding tissues in the extraction wound reduced enzymatic activity and was more severe in lathyric rats. Ultrastructurally, the osteoclasts of control rats had abundant mitochondria and a well-developed ruffled border. In the resorbing area, crystalline material and phosphotungstic acid positive layer below it were observed. The cytoplasmic organellae and ruffled border were poorly developed in the osteoclasts of lathyric rats.<BR>The findings suggest that bone resorption is a necessary process for healing on extraction wound to remove the injured tissue, and that in lathyric condition the activity of osteoclast was depressed and numerous osteoclasts were engaged in bone resorption.

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