Magnesium Deficiency and Hypertension: Correlation Between Magnesium-Deficient Diets and Microcirculatory Changes in Situ

DOI Web Site 被引用文献17件
  • Burton M. Altura
    Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn 11203
  • Bella T. Altura
    Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn 11203
  • Asefa Gebrewold
    Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn 11203
  • Hartmut Ising
    Bundesgesundheitsamt, Berlin, Federal Republic of Germany
  • Theo Gunther
    Institut für Molekularbiologie und Biochemie, Freie Universität, Berlin

抄録

<jats:p>Rats maintained for 12 weeks on diets moderately or more severely deficient in magnesium showed significant elevations in arterial blood pressure compared to control animals. Examination of the mesenteric microcirculation in situ revealed that dietary magnesium deficiency resulted in reduced capillary, postcapillary, and venular blood flow concomitant with reduced terminal arteriolar, precapillary sphincter, and venular lumen sizes. The greater the degree of dietary magnesium deficiency the greater the reductions in microvascular lumen sizes. These findings may provide a rationale for the etiology, as well as treatment, of some forms of hypertensive vascular disease.</jats:p>

収録刊行物

  • Science

    Science 223 (4642), 1315-1317, 1984-03-23

    American Association for the Advancement of Science (AAAS)

被引用文献 (17)*注記

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