Blockade of
            <i>N</i>
            -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

R. P. Simon, J. H. Swan, T. Griffiths, B. S. Meldrum

doi:10.1126/science.6093256

Blockade of <i>N</i> -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

DOI Web Site 被引用文献27件

R. P. Simon

Department of Neurology, Institute of Psychiatry, De Crespigny Park, London, England SES 8AF
J. H. Swan

Department of Neurology, Institute of Psychiatry, De Crespigny Park, London, England SES 8AF
T. Griffiths

Department of Neurology, Institute of Psychiatry, De Crespigny Park, London, England SES 8AF
B. S. Meldrum

Department of Neurology, Institute of Psychiatry, De Crespigny Park, London, England SES 8AF

抄録

<jats:p> In rats ischemia of the forebrain induced by a 30-minute occlusion of the carotid artery, followed by 120 minutes of arterial reperfusion, produced ischemic lesions of selectively vulnerable pyramidal cells in both hippocampi. Focal microinfusion into the dorsal hippocampus of 2-amino-7-phosphonoheptanoic acid, an antagonist of excitation at the <jats:italic>N</jats:italic> -methyl-D-aspartate-preferring receptor, before ischemia was induced protected against the development of ischemic damage. It is proposed that excitatory neurotransmission plays an important role in selective neuronal loss due to cerebral ischemia. </jats:p>