Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells.
抄録
<jats:p>Human IL-1, recombinant murine IL-1 and E. coli LPS were found to be potent inducers of plasminogen activator (PA)-inhibitor activity, both in vivo, in rats, as well as in cultured human endothelial cells. In vivo, LPS rapidly and dose-dependently (0.01-1,000 micrograms/kg) increased plasma PA-inhibitor activity. Infusion of IL-1 into rats resulted in a small but significant increase in PA-inhibitor activity in rat plasma. Likewise, in cultured human umbilical vein endothelial cells, LPS and IL-1 induced increased synthesis of PA-inhibitor. We suggest that the induced rat plasma inhibitor might be of endothelial origin.</jats:p>
収録刊行物
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- The Journal of experimental medicine
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The Journal of experimental medicine 163 (5), 1260-1266, 1986-05-01
Rockefeller University Press
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詳細情報 詳細情報について
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- CRID
- 1360292620506990720
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- NII論文ID
- 80002921125
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- ISSN
- 15409538
- 00221007
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- データソース種別
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