Central Projections of Identified, Unmyelinated (C) Afferent Fibers Innervating Mammalian Skin

DOI Web Site 被引用文献26件
  • Y. Sugiura
    Department of Physiology University of North Carolina at Chapel Hill Chapel Hill, NC 27514.
  • C. L. Lee
    Department of Physiology University of North Carolina at Chapel Hill Chapel Hill, NC 27514.
  • E. R. Perl
    Department of Physiology University of North Carolina at Chapel Hill Chapel Hill, NC 27514.

抄録

<jats:p> Unmyelinated (C) fibers are the most numerous sensory elements of mammalian peripheral nerve and comprise many of those responsible for initiating pain and temperature reactions; however, direct evidence has been lacking as to where and how these fibers terminate in the central nervous system. A plant lectin ( <jats:italic>Phaseolus vulgaris</jats:italic> leukoagglutinin) was applied intracellularly by iontophoresis as an immunocytochemical marker. This permitted visualization of the central terminations of cutaneous C sensory fibers that had been identified by the nature of stimuli that excited them. The central branch of C-fiber units arborized and terminated mainly in the superficial layers of the spinal dorsal horn in defined patterns that related to their functional attributes. Thus, the superficial dorsal horn seems to act as a processing station for signals from fine sensory fibers. </jats:p>

収録刊行物

  • Science

    Science 234 (4774), 358-361, 1986-10-17

    American Association for the Advancement of Science (AAAS)

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