Rheumatoid Factor Secretion from Human Leu-1 ⁺ B Cells

• Richard R. Hardy

  Institute for Molecular and Cellular Biology, Osaka University, 1-3, Yamada-Oka, Suita, Osaka 565, Japan.

• Kyoko Hayakawa

  Institute for Molecular and Cellular Biology, Osaka University, 1-3, Yamada-Oka, Suita, Osaka 565, Japan.

• Masatoshi Shimizu

  Osaka-Minami National Hospital, Kawachi- nagano, Osaka 586, Japan.

• Katsuhiko Yamasaki

  Institute for Molecular and Cellular Biology, Osaka University, 1-3, Yamada-Oka, Suita, Osaka 565, Japan.

• Tadamitsu Kishimoto

  Institute for Molecular and Cellular Biology, Osaka University, 1-3, Yamada-Oka, Suita, Osaka 565, Japan.

抄録

A human B cell subpopulation identifiable by the expression of the cell surface antigen Leu-1 (CD5) is responsible for most of the immunoglobulin M rheumatoid factor secreted in vitro after the cells are stimulated with Staphylococcus aureus . The ability of B cells bearing the Leu-1 marker (Leu-1 + ) to secrete rheumatoid factor is present early in development and extends to adulthood, since Leu-1 + B cells from cord blood and from peripheral blood lymphocytes of both normal adults and patients with certain autoimmune conditions secrete rheumatoid factor in comparable amounts. The neonatal enrichment of Leu-1 + B cells, the presence of Leu-1 + B cells in increased frequencies in patients with autoimmune disease, and the involvement of Leu-1 + B cells in autoantibody secretion suggest both developmental and functional homologies between this human B cell subpopulation and the murine Ly-1 B cell subpopulation.

収録刊行物

• Science

  Science 236 (4797), 81-83, 1987-04-03

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360011146237313792
• NII論文ID: 80003313282
• DOI: 10.1126/science.3105057
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.3105057
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