The Regulation of Natural Anticoagulant Pathways

DOI Web Site 26 Citations
  • Charles T. Esmon
    Thrombosis/Hematology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.

Abstract

<jats:p>Vascular endothelium plays an active role in preventing blood clot formation in vivo. One mechanism by which prevention is achieved involves a cell surface thrombin-binding protein, thrombomodulin, which converts thrombin into a protein C activator. Activated protein C then functions as an anticoagulant by inactivating two regulatory proteins of the coagulation system, factors Va and VIIIa. The physiological relevance of the protein C anticoagulant pathway is demonstrated by the identification of homozygous protein C-deficient infants with severe thrombotic complications. Recent studies suggest that this pathway provides a link between inflammation and coagulation.</jats:p>

Journal

  • Science

    Science 235 (4794), 1348-1352, 1987-03-13

    American Association for the Advancement of Science (AAAS)

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