Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

DOI Web Site 被引用文献47件
  • Clifford M. Snapper
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
  • William E. Paul
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

抄録

<jats:p>Gamma interferon (IFN-γ) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-4, are T cell-derived lymphokines that have potent effects on B cell proliferation and differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-γ stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF-1 has powerful effects in promoting switching to the expression of IgG1 and IgE but markedly inhibits IgM, IgG3, IgG2a, and IgG2b. These results indicate that BSF-1 and IFN-γ as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotype responses. The effects of IFN-γ and BSF-1 on isotype expression are independent.</jats:p>

収録刊行物

  • Science

    Science 236 (4804), 944-947, 1987-05-22

    American Association for the Advancement of Science (AAAS)

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