びまん性汎細気管支炎にたいするエリスロマイシン少量長期投与の臨床効果に関する研究　　４年間の治療成績

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  • Clinical effect of low-dose long-term erythromycin chemotherapy on diffuse panbronchiolitis.

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To date, no effective treatment has surfaced for diffuse panbronchiolitis (DPB), which has been known in Japan as a type of chronic obstructive pulmonary disease with a grave prognosis.<br>Eighteen patients with DPB, 16 cases of which were infected with H. influenzae and the other two with P. aerginosa, were treated with 600mg of Erythromycin (EM) per day for 19.8 months on the average. After the therapy, dyspnea upon exertion, body weight, chest X-ray findings, pulmonary function data and PaO2 level were confirmed to be significantly improved. The characteristic high titer of cold hemagglutinin was reduced along with the IgM level. No substantial side effects were noted, nor was any change found in the bacterial flora in the sputum except in one case.<br>In the nine cases completing the therapy, no essential clinical data differences were observed between the end of therapy and final observation over an average of 11.6 months, although four cases relapsed, with two of them recovering again through EM remedication.<br>The EM effect on DPB in this treatment is principally suppression of tissue response in the continuous bacterial infection of the lower air tract, rather than bacterial control. Accordingly, low-dose, long-term EM chemotherapy is useful in the treatment of DPB.

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