Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.
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- J Gauldie
- Department of Pathology, McMaster University, Hamilton, ON, Canada.
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- C Richards
- Department of Pathology, McMaster University, Hamilton, ON, Canada.
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- D Harnish
- Department of Pathology, McMaster University, Hamilton, ON, Canada.
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- P Lansdorp
- Department of Pathology, McMaster University, Hamilton, ON, Canada.
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- H Baumann
- Department of Pathology, McMaster University, Hamilton, ON, Canada.
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<jats:p>One of the oldest and most preserved of the homeostatic responses of the body to injury is the acute phase protein response associated with inflammation. The liver responds to hormone-like mediators by the increased synthesis of a series of plasma proteins called acute phase reactants. In these studies, we examined the relationship of hepatocyte-stimulating factor derived from peripheral blood monocytes to interferon beta 2 (IFN-beta 2), which has been cloned. Antibodies raised against fibroblast-derived IFN-beta having neutralizing activity against both IFN-beta 1 and -beta 2 inhibited the major hepatocyte-stimulating activity derived from monocytes. Fibroblast-derived mediator elicited the identical stimulated response in human HepG2 cells and primary rat hepatocytes as the monocyte cytokine. Finally, recombinant-derived human B-cell stimulatory factor type 2 (IFN-beta 2) from Escherichia coli induced the synthesis of all major acute phase proteins studied in human hepatoma HepG2 and primary rat hepatocyte cultures. These data demonstrate that monocyte-derived hepatocyte-stimulating factor and IFN-beta 2 share immunological and functional identity and that IFN-beta 2, also known as B-cell stimulatory factor and hybridoma plasmacytoma growth factor, has the hepatocyte as a major physiologic target and thereby is essential in controlling the hepatic acute phase response.</jats:p>
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 84 (20), 7251-7255, 1987-10
Proceedings of the National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1361137045438921600
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- NII論文ID
- 80003653714
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- NII書誌ID
- AA10808769
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- ISSN
- 10916490
- 00278424
- http://id.crossref.org/issn/00278424
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