Vβ-Specific Stimulation of Human T Cells by Staphylococcal Toxins

• John Kappler

• Brian Kotzin

• Lynne Herron

• Erwin W. Gelfand

• Robert D. Bigler

• Arthur Boylston

• Stefan Carrel

• David N. Posnett

• Yongwon Choi

• Philippa Marrack

抄録

The staphylococcal toxins are responsible for a number of diseases in man and other animals. Many of them have also long been known to be powerful T cell stimulants. They do not, however, stimulate all T cells. On the contrary, each toxin reacts with human T cells bearing particular Vβ sequences as part of their receptors for major histocompatibility complex protein-associated antigen. The specificity of these toxins for Vβs puts them in the recently described class of superantigens and may account for the differential sensitivity of different individuals to the toxic effects of these proteins.

収録刊行物

• Science

  Science 244 (4906), 811-813, 1989-05-19

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360574096446813568
• NII論文ID: 80004650556
• DOI: 10.1126/science.2524876
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.2524876
• データソース種別:
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  • CiNii Articles