Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker

DOI Web Site 被引用文献37件
  • Charles A. Czeisler
    Center for Circadian and Sleep Disorders Medicine, Division o fEndocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115
  • Richard E. Kronauer
    Division of Applied Sciences, Harvard University, Cambridge, MA 02138.
  • James S. Allan
    Center for Circadian and Sleep Disorders Medicine, Division o fEndocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115
  • Jeanne F. Duffy
    Center for Circadian and Sleep Disorders Medicine, Division o fEndocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115
  • Megan E. Jewett
    Center for Circadian and Sleep Disorders Medicine, Division o fEndocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115
  • Emery N. Brown
    Center for Circadian and Sleep Disorders Medicine, Division o fEndocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115
  • Joseph M. Ronda
    Center for Circadian and Sleep Disorders Medicine, Division o fEndocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115

抄録

<jats:p>The response of the human circadian pacemaker to light was measured in 45 resetting trials. Each trial consisted of an initial endogenous circadian phase assessment, a three-cycle stimulus which included 5 hours of bright light per cycle, and a final phase assessment. The stimulus induced strong (type 0) resetting, with responses highly dependent on the initial circadian phase of light exposure. The magnitude and direction of the phase shifts were modulated by the timing of exposure to ordinary room light, previously thought to be undetectable by the human pacemaker. The data indicate that the sensitivity of the human circadian pacemaker to light is far greater than previously recognized and have important implications for the therapeutic use of light in the management of disorders of circadian regulation.</jats:p>

収録刊行物

  • Science

    Science 244 (4910), 1328-1333, 1989-06-16

    American Association for the Advancement of Science (AAAS)

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