G <sub>1</sub> Events and Regulation of Cell Proliferation

DOI Web Site 被引用文献32件
  • Arthur B. Pardee
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.

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<jats:p> Cells prepare for S phase during the G <jats:sub>1</jats:sub> phase of the cell cycle. Cell biological methods have provided knowledge of cycle kinetics and of substages of G <jats:sub>1</jats:sub> that are determined by extracellular signals. Through the use of biochemical and molecular biological techniques to study effects of growth factors, oncogenes, and inhibitors, intracellular events during G <jats:sub>1</jats:sub> that lead to DNA synthesis are rapidly being discovered. Many cells in vivo are in a quiescent state (G <jats:sub>0</jats:sub> ), with unduplicated DNA. Cells can be activated to reenter the cycle during G <jats:sub>1</jats:sub> . Similarly, cells in culture can be shifted between G <jats:sub>0</jats:sub> and G <jats:sub>1</jats:sub> . These switches in and out of G <jats:sub>1</jats:sub> are the main determinants of post-embryonic cell proliferation rate and are defectively controlled in cancer cells. </jats:p>

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  • Science

    Science 246 (4930), 603-608, 1989-11-03

    American Association for the Advancement of Science (AAAS)

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