X-ray irradiation on blood products for the purpose of prevention of PT-GVHD.

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  • 輸血後移植片対宿主病の予防を目的とする血液製剤へのＸ線照射条件の検討

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Abstract

X-ray irradiation on blood products is a common method to prevent the risk of inducing PTGVHD, and has recently become to be used in Japan. We have tried X-ray irradiation on WB, CRC and PC using HITACHI X-ray Irradiation Apparatus MBR1520R, and studied its practical usefulness.<br>In case of irradiation on blood bags as the minimum dose of 1, 500 rads, these conditions are thought to be practical: 1) the use of 1.0mm Al filter 2) the distance of 550nm from X-ray source 3) irradiation on 4 bags at the same time. But, it has also been noticed that total doses and qualities of X-ray absorbed into blood were different between upper and lower side of the bag. Bloods on upper side absorbed much doses and a wide range of X-ray, on the other hand, bloods on lower side absorbed less doses and hard X-ray.<br>In these conditions, irradiated lymphocytes showed a complete inhibition of thymidine uptake in MLC test, still had 15% of activity in PHA stimulation. The qualities of other blood components have not changed before and after irradition.<br>X-ray irradiation is useful in a routine work of blood center, but problems of proper doses and a uniformity of irradiation are remained to be sloved.

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