Mechanism of Cell Damage by Ultrasound in Combination with Hematoporphyrin

• Shin‐ichiro Umemura

• Nagahiko Yumita

• Ryuichiro Nishigaki

• Koshiro Umemura

抄録

The mechanism of cell damage by ultrasound in combination with hematoporphyrin was studied. Mouse sarcoma 180 cell suspensions were exposed to ultrasound for up to 60 s in the presence and absence of hematoporphyrin, with and without active oxygen scavengers. The cell damage enhancement by hematoporphyrin was suppressed by adding histidine but not by mannitol. The enhancement was doubled in rate by substitution of deuterium oxide medium for normal water. Sonoluminescence was produced in a saline solution under similar acoustic conditions and observed to have spectral components that can excite hematoporphyrin molecules. These results suggest that cell damage enhancement is probably mediated via singlet oxygen generated by ultrasonically activated hematoporphyrin.

収録刊行物

• Japanese Journal of Cancer Research

  Japanese Journal of Cancer Research 81 (9), 962-966, 1990-09

  Wiley

キーワード

• Cancer Research
• Oncology

詳細情報

• CRID: 1360574096079668352
• NII論文ID: 80005444469
• DOI: 10.1111/j.1349-7006.1990.tb02674.x
• ISSN: 09105050
• ISSN: http://id.crossref.org/issn/09105050
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1349-7006.1990.tb02674.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1349-7006.1990.tb02674.x
• Web Site: https://search.jamas.or.jp/link/ui/1992007349
• データソース種別:
  • Crossref
  • CiNii Articles