Effect of Cytochrome P450 Arachidonate Metabolites on Ion Transport in Rabbit Kidney Loop of Henle

  • Bruno Escalante
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595.
  • David Erlij
    Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203.
  • John R. Falck
    Department of Molecular Genetics, University of Texas, Health Science Center, Dallas, TX 75235.
  • John C. McGiff
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595.

抄録

<jats:p> In the medullary segment of the thick ascending limb of the loop of Henle (mTALH), arachidonic acid (AA) is metabolized by a cytochrome P450-dependent monooxygenase to products that affect ion transport. The linkage between changes in ion transport and AA metabolism in isolated cells of the mTALH was examined. AA produced a concentration-dependent inhibition of <jats:sup>86</jats:sup> Rb uptake—an effect that was prevented by selective blockade of cytochrome P450 monooxygenases. Inhibition by cytochrome P450 blockade of the effect of AA on <jats:sup>86</jats:sup> Rb uptake could be circumvented by addition of the principal products of AA metabolism in the mTALH. </jats:p>

収録刊行物

  • Science

    Science 251 (4995), 799-802, 1991-02-15

    American Association for the Advancement of Science (AAAS)

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