Effect of Cytochrome P450 Arachidonate Metabolites on Ion Transport in Rabbit Kidney Loop of Henle
-
- Bruno Escalante
- Department of Pharmacology, New York Medical College, Valhalla, NY 10595.
-
- David Erlij
- Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203.
-
- John R. Falck
- Department of Molecular Genetics, University of Texas, Health Science Center, Dallas, TX 75235.
-
- John C. McGiff
- Department of Pharmacology, New York Medical College, Valhalla, NY 10595.
抄録
<jats:p> In the medullary segment of the thick ascending limb of the loop of Henle (mTALH), arachidonic acid (AA) is metabolized by a cytochrome P450-dependent monooxygenase to products that affect ion transport. The linkage between changes in ion transport and AA metabolism in isolated cells of the mTALH was examined. AA produced a concentration-dependent inhibition of <jats:sup>86</jats:sup> Rb uptake—an effect that was prevented by selective blockade of cytochrome P450 monooxygenases. Inhibition by cytochrome P450 blockade of the effect of AA on <jats:sup>86</jats:sup> Rb uptake could be circumvented by addition of the principal products of AA metabolism in the mTALH. </jats:p>
収録刊行物
-
- Science
-
Science 251 (4995), 799-802, 1991-02-15
American Association for the Advancement of Science (AAAS)
- Tweet
キーワード
詳細情報
-
- CRID
- 1362262944927004288
-
- NII論文ID
- 80005759842
-
- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
-
- データソース種別
-
- Crossref
- CiNii Articles