冠動脈, 頸動脈, 頭蓋内脳動脈硬化の危険因子についての検討

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  • Clinical Studies of Risk Factors of Coronary, Carotid and Cerebral Atherosclerosis

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With the participation of 77 patients (55 men and 22 women) suffering from ischemic heart disease, we studied the relationship between coronary atherosclerosis, carotid atherosclerosis and cerebral atherosclerosis (arteriolosclerosis). At the same time we studied the risk factors behind each type of atherosclerosis. Coronary atherosclerosis was assessed by the number of significant stenotic major vessels and its Gensini score, carotid atherosclerosis was assessed by its carotid ultrasonographic score, while cerebral arteriolosclerosis was assessed by its brain CT score. To detect the significant risk factors of each type of atherosclerosis, various risk factors (aging, hyperlipidemia, hypertension, diabetes mellitus, smoking and obesity) were analized by applying the multivalidation technique. Our results were as follows:<br>1) As coronary atherosclerosis progressed, carotid atherosclerosis and cerebral arteriolosclerosis also tended to progress.<br>2) Age and hyperlipidemia were significant risk factors of coronary atherosclerosis, and so it is important to control hyperlipidemia to prevent ischemic heart disease.<br>3) Age was the only significant risk factor of carotid atherosclerosis.<br>4) Age and hypertension were significant risk factors of cerebral arteriolosclerosis. It is, therefore, important to control blood pressure to prevent cerebral arteriolosclerosis.

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