Ｃ型肝炎ウイルス（ＨＣＶ）抗体スクリーニングによる輸血後肝炎の減少

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  • Reduction of incidence fo post-transfusion hepatitis(PTH) by donor blood screening for hepatitis C virus(HCV) antibody.

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We examined the effect of donor blood screening of HCV antibody on the reduction of the incidence of posttransfusion hepatitis (PTH).<br>Before this screening period, from September 1 to November 13, 1989, 263 cases in Hokkaido area were given with the mean dose of 11.0 units and followed for more than 3 months. Fourteen cases were diagnosed as posttransfusion hepatitis (5.3%), i. e. 9 cases definite, and 5 cases probable. Eight patients were diagnosed as hepatitis C, since either sera from patients themselves or donor blood samples turned out to be positive for aniti-HCV retrospectively.<br>After the screening period, from November 14, 1989 to July 31, 1990, 555 cases were given with the mean dose of 14.2 units and followed for more than 3 months. Twelve cases were diagnosed as PTH (2.2%), i. e. 5 cases definite, and 7 cases probable. In 5 cases patient's anti-HCV converted to positive and in one of those cases two of the implicated donors seroconverted after the blood donation.<br>In conclusion, it was revealed that incidence of PTH reduced from 5.3% (14/263) to 2.2% (12/555) significantly by HCV antibody screening of donor blood.

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  • 日本輸血学会雑誌

    日本輸血学会雑誌 37 (5), 632-637, 1991

    一般社団法人 日本輸血・細胞治療学会

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