Evidence for common ancestry of a chestnut blight hypovirulence-associated double-stranded RNA and a group of positive-strand RNA plant viruses.
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- E V Koonin
- Department of Biology, Texas A&M University, College Station 77843.
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- G H Choi
- Department of Biology, Texas A&M University, College Station 77843.
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- D L Nuss
- Department of Biology, Texas A&M University, College Station 77843.
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- R Shapira
- Department of Biology, Texas A&M University, College Station 77843.
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- J C Carrington
- Department of Biology, Texas A&M University, College Station 77843.
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<jats:p>Computer-assisted analysis of the putative polypeptide products encoded by the two open reading frames present in a large virus-like double-stranded RNA, L-dsRNA, associated with hypovirulence of the chestnut blight fungus, Cryphonectria parasitica, revealed five distinct domains with significant sequence similarity to previously described conserved domains within plant potyvirus-encoded polyproteins. These included the putative RNA-dependent RNA polymerase, RNA helicase, two papain-like cysteine proteases related to the potyvirus helper-component protease, and a cysteine-rich domain of unknown function similar to the N-terminal portion of the potyvirus helper-component protein. Phylogenetic trees derived from the alignment of the polymerase domains of L-dsRNA, a subset of positive-stranded RNA viruses, and double-stranded RNA viruses, using three independent algorithms, suggested that the hypovirulence-associated dsRNA and potyvirus genomes share a common ancestry. However, comparison of the organization of the conserved domains within the encoded polyproteins of the respective viruses indicated that the proposed subsequent evolution involved extensive genome rearrangement.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 88 (23), 10647-10651, 1991-12
Proceedings of the National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1362544420519088640
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- NII論文ID
- 80006245752
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- NII書誌ID
- AA10808769
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- ISSN
- 10916490
- 00278424
- http://id.crossref.org/issn/00278424
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