Antiarrhythmic effects of MS-551, a new class III antiarrhythmic agent, on canine models of ventricular arrhythmias

• Kamiya Joji

  Department of Pharmacology, Institute of Biological Science, Mitsui Pharmaceuticals, Inc.

• Ishii Masaaki

  Department of Pharmacology, Institute of Biological Science, Mitsui Pharmaceuticals, Inc.

• Katakami Tsutomu

  Life Science Laboratory, Central Research Institute, Mitsui Toatsu Chemicals, Inc.

書誌事項

タイトル別名

• Antiarrhythmic Effects of MS-551, a New Class III Antiarrhythmic Agent, on Canine Models of Ventricular Arrhythmia.

抄録

-The antiarrhythmic effects of MS-551, which prolongs cardiac action potential duration without affecting the maximum upstroke velocity of the action potential, were assessed in three different canine ventricular arrhythmia models: 1) ventricular tachycardia (VT) induced by electrical stimuli 3-5 days after myocardial infarction, 2) spontaneous ventricular tachyarrhythmias 24-48 hr after two-stage coronary ligation and 3) ventricular tachyarrhythmias induced by digitalis. Intravenous administration of MS-551 (0.1-1 mg/kg) decreased the susceptibility in 10 dogs out of 13 to VT or ventricular fibrillation evoked by programmed electrical stimulation (PES) delivered to the ventricular septum 3-5 days after myocardial infarction. Oral administration of MS-551 (3 mg/kg) also decreased the susceptibility to VT evoked by PES in 7 out of 10 conscious postinfarction dogs. Concurrently, intravenous (0.1-1 mg/kg) or oral (3 mg/kg) administration of MS-551 produced increases in the ventricular effective refractory periods (ERP) by 7 ± 1%-17 ± 3% or 13 ± 2%, respectively. Similarly, d-sotalol (0.3-3 mg/kg, i.v. and 10 mg/kg, p.o.) decreased the susceptibility to VT with increased ERP. However, MS-551 (1 and 10 mg/kg, i.v.) failed to inhibit both canine two-stage coronary ligation arrhythmia and digitalis arrhythmia. These results suggest that MS-551 is a pure class III antiarrhythmic drug which may be effective in the treatment of life-threatening reentrant tachyarrhythmias, but not in automaticity arrhythmias.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 58 (2), 107-115, 1992

  公益社団法人 日本薬理学会

キーワード

• Pharmacology

詳細情報

• CRID: 1390001204285832576
• NII論文ID: 130000833308
• NII論文ID: 80006351454
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.58.107
• COI: 1:CAS:528:DyaK38XhvVOksro%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• PubMed: 1507517
• Web Site: https://search.jamas.or.jp/link/ui/1993146329
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可