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- 小野寺 秀記
- 京都府立与謝の海病院呼吸器科
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- 笠松 美宏
- 京都府立与謝の海病院呼吸器科
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- 竹村 周平
- 京都府立医科大学第1内科
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- 中原 梨佐
- 京都府立医科大学第1内科
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- 一尾 直子
- 京都府立医科大学第1内科
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- 土井 たかし
- 京都府立医科大学第1内科
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- 岡本 雅之
- 京都府立医科大学第1内科
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- 柳田 国雄
- 京都府立医科大学第1内科
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- 福田 亙
- 京都府立医科大学第1内科
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- 田中 真理子
- 京都府立医科大学第1内科
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- 出口 雅子
- 京都府立医科大学第1内科
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- 上田 正博
- 京都府立医科大学第1内科
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- 田中 惇夫
- 京都府立医科大学第1内科
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- 杉野 成
- 京都府立医科大学第1内科
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- 近藤 元治
- 京都府立医科大学第1内科
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- 林 英夫
- 京都第二赤十字病院第3内科
書誌事項
- タイトル別名
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- Immunomodulating effects of the immunoglobulin therapy to the complement receptors on the peripheral leukocytes in patients with diffuse panbronchiolitis.
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抄録
Immunoglobulin (IG) therapy was received 7 times to 3 patients with diffuse panbronchiolitis (DPB), and its immunomodulating effects to peripheral blood cells were investigated. IG therapy decreased the erythrocytes counts and the expression of complement receptors on the peripheral monocytes and granulocytes transiently. Etiology of a transient decrease of erythrocytes wasn't clarified but it was suggested that IG therapy induced the erythrocytes' accumulation to reticuloendothelial system for the clearance of immune complex. IG therapy decreased expression of CR 1, CR 2 and CR 3 on monocytes and CR l on granulocytes but didn't alter deposition of C 3 on those cells, so that accerelated interiorization or capping, and impaired regulation of complement receptors expressing on those cells might be evoked by IG therapy. By contraries, increase of these complement receptors' expression were observed immediately after IG administration in some cases. Those altered expression of complement receptors suspected to contribute to the enhancement of phagocytotic activity and contribute to the accerelated release of some chemical mediators.<br>In vitro experiment on normal human volunteers, both intact globulin and F (ab')2globulin increased expression of CR l on monocytes and granulocytes, and also increased expression of HLA•DR on monocytes. Only intact globulin increased expression of IL-2 receptors on monocytes, and decreased expression of HLA•DR on lymphocytes. These results suggested the role of IG therapy would be enhancement of opsonizing effect, and on the other hand might be immunomodulation with cellular immune reaction in patients with DPB.
収録刊行物
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- 日本臨床免疫学会会誌
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日本臨床免疫学会会誌 15 (2), 127-134, 1992
日本臨床免疫学会
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詳細情報 詳細情報について
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- CRID
- 1390282679626725760
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- NII論文ID
- 130000851615
- 80006477270
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- ISSN
- 13497413
- 09114300
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可