Programmed Death of T Cells in HIV-1 Infection

Linde Meyaard, Sigrid A. Otto, Richard R. Jonker, M. Janneke Mijnster, René P. M. Keet, Frank Miedema

doi:10.1126/science.1352911

Programmed Death of T Cells in HIV-1 Infection

DOI Web Site 被引用文献24件

Linde Meyaard

Department of Clinical Viro-lmmunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.
Sigrid A. Otto

Department of Clinical Viro-lmmunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.
Richard R. Jonker

Department of Molecular Pathology, TNO Institute of Applied Radiobiology and Immunology, Rijswijk, The Netherlands.
M. Janneke Mijnster

Netherlands Institute for Brain Research, Amsterdam, The Netherlands.
René P. M. Keet

Department of Infectious Diseases, Municipal Health Service, Amsterdam, The Netherlands.
Frank Miedema

Department of Clinical Viro-lmmunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.

抄録

<jats:p> In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4 <jats:sup>+</jats:sup> and CD8 <jats:sup>+</jats:sup> T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency. </jats:p>