Cloning of the γ Chain of the Human IL-2 Receptor

DOI Web Site 45 Citations
  • Toshikazu Takeshita
    Department of Microbiology, Tohoku University School of Medicine, Sendai 980, Japan.
  • Hironobu Asao
    Department of Microbiology, Tohoku University School of Medicine, Sendai 980, Japan.
  • Kiyoshi Ohtani
    Department of Microbiology, Tohoku University School of Medicine, Sendai 980, Japan.
  • Naoto Ishii
    Department of Microbiology, Tohoku University School of Medicine, Sendai 980, Japan.
  • Satoru Kumaki
    Department of Microbiology, Tohoku University School of Medicine, Sendai 980, Japan.
  • Nobuyuki Tanaka
    Department of Microbiology, Tohoku University School of Medicine, Sendai 980, Japan.
  • Hiroshi Munakata
    Department of Biochemistry, Tohoku University School of Medicine, Sendai 980, Japan.
  • Masataka Nakamura
    Department of Microbiology, Tohoku University School of Medicine, Sendai 980, Japan.
  • Kazuo Sugamura
    Department of Microbiology, Tohoku University School of Medicine, Sendai 980, Japan.

Abstract

<jats:p>A third subunit, the γ chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The γ chain is necessary for the formation of the high- and intermediate-affinity receptors, which consist of αβγ heterotrimers and βγ heterodimers, respectively. The IL-2R on murine fibroblastoid cells can be internalized after binding IL-2 only if the γ chain is present; α and β are insufficient for internalization. Thus, the γ chain is an indispensable component of the functional IL-2R.</jats:p>

Journal

  • Science

    Science 257 (5068), 379-382, 1992-07-17

    American Association for the Advancement of Science (AAAS)

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