シェーグレン症候群に続発した高γグロブリン血症性紫斑の１例

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  • A Case of Hypergammaglobulinemic Purpura Associated with Sjoegren's Syndrome.

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A 70-year-old woman with Sjögren' s syndrome, hypergammaglobulinemic purpura, and B-cell malignant lymphoma with a nine-year history of foreign body sensation in the eyes, thirst, and lower extremity purpura and a fourmonth history of chest pain and abnormal chest shadow is reported. The purpuric regions were characterized histologically by necrotizing angiitis and lymphocytic vasculitis, and direct fluorescent antibody technique revealed IgA and C3 deposition in the vascular walls. Ultracentrifugation of serum revealed intermediate complex, and recombination of immunoglobulin gene JH chains was seen in pleural effusion cells. Following four cycles of CVP therapy (cyclophosphamide, vincristi e, predonisolone) serum gammaglobulin values were normalized and the purpura disappeared.

収録刊行物

  • 皮膚

    皮膚 35 (2), 247-252, 1993

    日本皮膚科学会大阪地方会

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