POSSIBLE USEFULNESS OF CEPHEM ANTIBIOTICS WITH ANTI-STAPHYLOCOCCAL ACTIVITY FOR PREVENTING THE SPREAD OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
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- HIKIDA MUNEO
- Biological Research Laboratories, Lederle (Japan), Ltd.
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- MORI MASAHIKO
- Biological Research Laboratories, Lederle (Japan), Ltd.
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- YOSHIDA MASUHITO
- Biological Research Laboratories, Lederle (Japan), Ltd.
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- YOKOTA TAKESHI
- Department of Microbiology, Faculty of Medicine, Juntendo University
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抄録
The validity of clinical use of cephem antibiotics for preventing the spread of methicillin-resistant Staphylococcus aureus (MRSA) was investigated using a methicillin-susceptible S. aureus (MSSA) carrying mecA gene. It became evident that drug with anti-staphylococcal activity, such as cefuzonam (CZON) or cefazolin (CEZ), has comparatively low selectivity of high-level methicillin resistant clones (methicillin MIC range from 25 to 800 μg/ml) from MSSA carrying mecA gene among cephem antibiotics tested. At concentrations over 1.56 μg/ml of both CZON and CEZ, about a 2-3 log10 decrease in viable count was observed. Therefore, it seems that much satisfactory disappearance of bacterial cells can be obtained in cooperation with host defence mechanisms.
収録刊行物
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 46 (9), 836-839, 1993
公益財団法人 日本感染症医薬品協会
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詳細情報
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- CRID
- 1390001205494219136
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- NII論文ID
- 80007245991
- 130004130931
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- COI
- 1:CAS:528:DyaK2cXhsFejsbo%3D
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- ISSN
- 21865477
- 03682781
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- PubMed
- 8254903
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可