Association of Intestinal Peptide Transport with a Protein Related to the Cadherin Superfamily

DOI Web Site 被引用文献12件
  • Anne H. Dantzig
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • JoAnn Hoskins
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Linda B. Tabas
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Stuart Bright
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Robert L. Shepard
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Ivan L. Jenkins
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Dale C. Duckworth
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • J. Richard Sportsman
    Terrapin Technologies, San Francisco, CA 94080, USA.
  • Daniel Mackensen
    Inc., San Diego, CA 92121, USA.
  • Paul R. Rosteck
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
  • Paul L. Skatrud
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

抄録

<jats:p>The first step in oral absorption of many medically important peptide-based drugs is mediated by an intestinal proton-dependent peptide transporter. This transporter facilitates the oral absorption of β-lactam antibiotics and angiotensin-converting enzyme inhibitors from the intestine into enterocytes lining the luminal wall. A monoclonal antibody that blocked uptake of cephalexin was used to identify and clone a gene that encodes an approximately 92-kilodalton membrane protein that was associated with the acquisition of peptide transport activity by transport-deficient cells. The amino acid sequence deduced from the complementary DNA sequence of the cloned gene indicated that this transport-associated protein shares several conserved structural elements with the cadherin superfamily of calcium-dependent, cell-cell adhesion proteins.</jats:p>

収録刊行物

  • Science

    Science 264 (5157), 430-433, 1994-04-15

    American Association for the Advancement of Science (AAAS)

被引用文献 (12)*注記

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