A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules
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- M. Kovacsovics-Bankowski
- Division of Lymphocyte Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
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- K. L. Rock
- Division of Lymphocyte Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
抄録
<jats:p>Peptides from endogenous proteins are presented by major histocompatibility complex class I molecules, but antigens (Ags) in the extracellular fluids are generally not. However, pathogens or particulate Ags that are internalized into phagosomes of macrophages (MØs) stimulate CD8 T cells. The presentation of these Ags is resistant to chloroquine but is blocked by inhibitors of the proteasome, a mutation in the TAP1-TAP2 transporter, and brefeldin A. Moreover, phagocytosis of a ribosomal-inactivating protein inhibited MØ protein synthesis. These results demonstrate that MØs transfer Ags from phagosomes into the cytosol and that endogenous and exogenous Ags use a final common pathway for class I presentation.</jats:p>
収録刊行物
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- Science
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Science 267 (5195), 243-246, 1995-01-13
American Association for the Advancement of Science (AAAS)
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詳細情報 詳細情報について
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- CRID
- 1361699995839776512
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- NII論文ID
- 80008093305
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
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