A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.

DOI Web Site 被引用文献35件
  • T K McDaniel
    Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD.
  • K G Jarvis
    Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD.
  • M S Donnenberg
    Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD.
  • J B Kaper
    Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD.

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<jats:p>Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.</jats:p>

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