Role of the Chaperone Protein Hsp104 in Propagation of the Yeast Prion-Like Factor [ <i>psi</i> ⁺ ]

• Yury O. Chernoff

  Department of Biological Sciences, University of Illinois, Chicago, IL 60607-7020, USA.

• Susan L. Lindquist

  Department of Molecular Genetics and Cell Biology and Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.

• Bun-ichiro Ono

  Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700, Japan.

• Sergei G. Inge-Vechtomov

  Department of Genetics, St. Petersburg State University, 199034 St. Petersburg, Russia.

• Susan W. Liebman

  Department of Biological Sciences, University of Illinois, Chicago, IL 60607-7020, USA.

抄録

The yeast non-Mendelian factor [ psi + ] has been suggested to be a self-modified protein analogous to mammalian prions. Here it is reported that an intermediate amount of the chaperone protein Hsp104 was required for the propagation of the [ psi + ] factor. Overproduction or inactivation of Hsp104 caused the loss of [ psi + ]. These results suggest that chaperone proteins play a role in prion-like phenomena, and that a certain level of chaperone expression can cure cells of prions without affecting viability. This may lead to antiprion treatments that involve the alteration of chaperone amounts or activity.

収録刊行物

• Science

  Science 268 (5212), 880-884, 1995-05-12

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363107371076700288
• NII論文ID: 80008293478
• DOI: 10.1126/science.7754373
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.7754373
• データソース種別:
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  • CiNii Articles