Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
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- G L Wang
- Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287-3914, USA.
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- B H Jiang
- Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287-3914, USA.
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- E A Rue
- Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287-3914, USA.
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- G L Semenza
- Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287-3914, USA.
抄録
<jats:p>Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells. We show that both HIF-1 subunits are basic-helix-loop-helix proteins containing a PAS domain, defined by its presence in the Drosophila Per and Sim proteins and in the mammalian ARNT and AHR proteins. HIF-1 alpha is most closely related to Sim. HIF-1 beta is a series of ARNT gene products, which can thus heterodimerize with either HIF-1 alpha or AHR. HIF-1 alpha and HIF-1 beta (ARNT) RNA and protein levels were induced in cells exposed to 1% O2 and decayed rapidly upon return of the cells to 20% O2, consistent with the role of HIF-1 as a mediator of transcriptional responses to hypoxia.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 92 (12), 5510-5514, 1995-06-06
Proceedings of the National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1364233270701220096
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- NII論文ID
- 80008367952
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- ISSN
- 10916490
- 00278424
- http://id.crossref.org/issn/00278424
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