Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

DOI Web Site 被引用文献146件
  • Mary Ann Pelleymounter
    Department of Neurobiology, Amgen, Inc., Thousand Oaks, CA 91320, USA.
  • Mary Jane Cullen
    Department of Neurobiology, Amgen, Inc., Thousand Oaks, CA 91320, USA.
  • Mary Beth Baker
    Department of Neurobiology, Amgen, Inc., Thousand Oaks, CA 91320, USA.
  • Randy Hecht
    Department of Recovery Process Development, Amgen, Inc., Thousand Oaks, CA 91320, USA.
  • Dwight Winters
    Department of Recovery Process Development, Amgen, Inc., Thousand Oaks, CA 91320, USA.
  • Thomas Boone
    Department of Recovery Process Development, Amgen, Inc., Thousand Oaks, CA 91320, USA.
  • Frank Collins
    Department of Neurobiology, Amgen, Inc., Thousand Oaks, CA 91320, USA.

抄録

<jats:p> C57BL/6J mice with a mutation in the <jats:italic>obese</jats:italic> ( <jats:italic>ob</jats:italic> )gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of glucose and insulin. In addition, metabolic rate, body temperature, and activity levels were increased by this treatment. None of these parameters was altered beyond the level observed in lean controls, suggesting that the OB protein normalized the metabolic status of the <jats:italic>ob</jats:italic> / <jats:italic>ob</jats:italic> mice. Lean animals injected with OB protein maintained a smaller weight loss throughout the 28-day study and showed no changes in any of the metabolic parameters. These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite. </jats:p>

収録刊行物

  • Science

    Science 269 (5223), 540-543, 1995-07-28

    American Association for the Advancement of Science (AAAS)

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