Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

• L. Arthur Campfield

• Françoise J. Smith

• Yves Guisez

• Rene Devos

• Paul Burn

抄録

The recent positional cloning of the mouse ob gene and its human homolog has provided the basis to investigate the potential role of the ob gene product in body weight regulation. A biologically active form of recombinant mouse OB protein was overexpressed and purified to near homogeneity from a bacterial expression system. Peripheral and central administration of microgram doses of OB protein reduced food intake and body weight of ob / ob and diet-induced obese mice but not in db / db obese mice. The behavioral effects after brain administration suggest that OB protein can act directly on neuronal networks that control feeding and energy balance.

収録刊行物

• Science

  Science 269 (5223), 546-549, 1995-07-28

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363951795979897600
• NII論文ID: 80008463725
• DOI: 10.1126/science.7624778
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.7624778
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  • CiNii Articles