Effect of pregnancy on plasma phenobarbital concentrations in rats.

• Moriyama Masahiro

• Domoto Haruyo

• Yamashita Syoichi

• Furuno Katsushi

• Oishi Ryozo

• Kawasaki Hiromu

• Gomita Yutaka

抄録

We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats. Animals were divided into four groups: (a) control, (b) pregnant, (c) phenobarbital-treated, and (d) phenobarbital-treated pregnant groups. The increase in body weight of nonpregnant or pregnant rats was not influenced by long-term phenobarbital treatment. Plasma phenobarbital concentrations during the period of long-term phenobarbital treatment with a fixed dosage by body weight were not significantly affected by pregnancy. Furthermore, pregnancy did not affect pharmacokinetic parameters of phenobarbital between 0.25 and 24h after administration. These results suggest that pregnancy does not influence on the pharmacokinetics of long-term phenobarbital treatment at a fixed dosage by body weight.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 49 (5), 237-240, 1995-10

  Okayama University Medical School

キーワード

• phenobarbital
• pharmacokinetics
• pregnancy
• plasma concentrations

詳細情報

• CRID: 1390290699606291072
• NII論文ID: 80008597449
• NII論文ID: 120002305684
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/30398
• PubMed: 8585393
• Web Site: https://ousar.lib.okayama-u.ac.jp/30398
• Web Site: https://search.jamas.or.jp/link/ui/1996103326
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • PubMed
  • CiNii Articles