Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)

DOI Web Site 45 Citations
  • Georg F. Weber
    G. F. Weber and H. Cantor, Division of Immunopathology, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
  • Samy Ashkar
    S. Ashkar and M. J. Glimcher, Department of Orthopedic Research, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Melvin J. Glimcher
    S. Ashkar and M. J. Glimcher, Department of Orthopedic Research, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Harvey Cantor
    G. F. Weber and H. Cantor, Division of Immunopathology, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

<jats:p>The CD44 family of surface receptors regulates adhesion, movement, and activation of normal and neoplastic cells. The cytokine osteopontin (Eta-1), which regulates similar cellular functions, was found to be a protein ligand of CD44. Osteopontin induces cellular chemotaxis but not homotypic aggregation, whereas the inverse is true for the interaction between CD44 and a carbohydrate ligand, hyaluronate. The different responses of cells after CD44 ligation by either osteopontin or hyaluronate may account for the independent effects of CD44 on cell migration and growth. This mechanism may also be exploited by tumor cells to promote metastasis formation.</jats:p>

Journal

  • Science

    Science 271 (5248), 509-512, 1996-01-26

    American Association for the Advancement of Science (AAAS)

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