An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

DOI Web Site 被引用文献7件
  • Steven Xanthoudakis
    Neurogenetics Program, Department of CNS Research, Hoffmann-La Roche, Nutley, NJ 07110, USA.
  • Joao P. B. Viola
    Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
  • Karen T. Y. Shaw
    Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
  • Chun Luo
    Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
  • James D. Wallace
    Neurogenetics Program, Department of CNS Research, Hoffmann-La Roche, Nutley, NJ 07110, USA.
  • Patricia T. Bozza
    Harvard Thorndike Laboratory and Charles A. Dana Research Institute, Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Daniel C. Luk
    Roche Institute of Molecular Biology at Hoffmann-La Roche, Inc., Nutley, NJ 07110, USA
  • Tom Curran
    Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Anjana Rao
    Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

抄録

<jats:p> Transcription factors of the NFAT family are thought to play a major role in regulating the expression of cytokine genes and other inducible genes during the immune response. The role of NFAT1 was investigated by targeted disruption of the NFAT1 gene. Unexpectedly, cells from NFAT1 <jats:sup>−/−</jats:sup> mice showed increased primary responses to <jats:italic>Leishmania major</jats:italic> and mounted increased secondary responses to ovalbumin in vitro. In an in vivo model of allergic inflammation, the accumulation of eosinophils and levels of serum immunoglobulin E were increased in NFAT1 <jats:sup>−/−</jats:sup> mice. These results suggest that NFAT1 exerts a negative regulatory influence on the immune response. </jats:p>

収録刊行物

  • Science

    Science 272 (5263), 892-895, 1996-05-10

    American Association for the Advancement of Science (AAAS)

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