The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

DOI Web Site 被引用文献64件
  • Jae-Young Koh
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, Post Office Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  • Sang W. Suh
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, Post Office Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  • Byoung J. Gwag
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, Post Office Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  • Yong Y. He
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, Post Office Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  • Chung Y. Hsu
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, Post Office Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  • Dennis W. Choi
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, Post Office Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

抄録

<jats:p>Zinc is present in presynaptic nerve terminals throughout the mammalian central nervous system and likely serves as an endogenous signaling substance. However, excessive exposure to extracellular zinc can damage central neurons. After transient forebrain ischemia in rats, chelatable zinc accumulated specifically in degenerating neurons in the hippocampal hilus and CA1, as well as in the cerebral cortex, thalamus, striatum, and amygdala. This accumulation preceded neurodegeneration, which could be prevented by the intraventricular injection of a zinc chelating agent. The toxic influx of zinc may be a key mechanism underlying selective neuronal death after transient global ischemic insults.</jats:p>

収録刊行物

  • Science

    Science 272 (5264), 1013-1016, 1996-05-17

    American Association for the Advancement of Science (AAAS)

被引用文献 (64)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ