Entorhinal-Hippocampal Interactions Revealed by Real-Time Imaging

DOI Web Site 34 Citations
  • Toshio Iijima
    T. Iijima, M. Ichikawa, T. Tominaga, G. Matsumoto, Molecular and Cellular Neuroscience Section, Electrotechnical Laboratory, 1-1-4 Umezono, Tsukuba, Ibaraki 305, Japan.
  • Menno P. Witter
    M. P. Witter, Graduate School for Neuroscience, Research Institute Neuroscience, Vrije Universiteit, Department of Anatomy and Embryology, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands.
  • Michinori Ichikawa
    T. Iijima, M. Ichikawa, T. Tominaga, G. Matsumoto, Molecular and Cellular Neuroscience Section, Electrotechnical Laboratory, 1-1-4 Umezono, Tsukuba, Ibaraki 305, Japan.
  • Takashi Tominaga
    T. Iijima, M. Ichikawa, T. Tominaga, G. Matsumoto, Molecular and Cellular Neuroscience Section, Electrotechnical Laboratory, 1-1-4 Umezono, Tsukuba, Ibaraki 305, Japan.
  • Riichi Kajiwara
    R. Kajiwara, Information Science, Tohoku University, Sendai 980, Japan.
  • Gen Matsumoto
    T. Iijima, M. Ichikawa, T. Tominaga, G. Matsumoto, Molecular and Cellular Neuroscience Section, Electrotechnical Laboratory, 1-1-4 Umezono, Tsukuba, Ibaraki 305, Japan.

Abstract

<jats:p>The entorhinal cortex provides the major cortical input to the hippocampus, and both structures have been implicated in memory processes. The dynamics of neuronal circuits in the entorhinal-hippocampal system were studied in slices by optical imaging with high spatial and temporal resolution. Reverberation of neural activity was detected in the entorhinal cortex and was more prominent when the inhibition due to γ-aminobutyric acid was slightly suppressed. Neural activity was transferred in a frequency-dependent way from the entorhinal cortex to the hippocampus. The entorhinal neuronal circuit could contribute to memory processes by holding information and selectively gating the entry of information into the hippocampus.</jats:p>

Journal

  • Science

    Science 272 (5265), 1176-1179, 1996-05-24

    American Association for the Advancement of Science (AAAS)

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