Identification of a pathogenicity island required for Salmonella survival in host cells.

DOI Web Site 被引用文献9件
  • H Ochman
    Department of Biology, University of Rochester, NY 14627, USA.
  • F C Soncini
    Department of Biology, University of Rochester, NY 14627, USA.
  • F Solomon
    Department of Biology, University of Rochester, NY 14627, USA.
  • E A Groisman
    Department of Biology, University of Rochester, NY 14627, USA.

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<jats:p>We have identified a region unique to the Salmonella typhimurium chromosome that is essential for virulence in mice. This region harbors at least three genes: two (spiA and spiB) encode products that are similar to proteins found in type III secretion systems, and a third (spiR) encodes a putative regulator. A strain with a mutation in spiA was unable to survive within macrophages but displayed wild-type levels of epithelial cell invasion. The culture supernatants of the spi mutants lacked a modified form of flagellin, which was present in the supernatant of the wild-type strain. This suggests that the Spi secretory apparatus exports a protease, or a protein that can alter the activity of a secreted protease. The "pathogenicity island" harboring the spi genes may encode the virulence determinants that set Salmonella apart from other enteric pathogens.</jats:p>

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