Complete Genome Sequence of the Methanogenic Archaeon, <b> <i>Methanococcus jannaschii</i> </b>

  • Carol J. Bult
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Owen White
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Gary J. Olsen
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Lixin Zhou
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Robert D. Fleischmann
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Granger G. Sutton
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Judith A. Blake
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Lisa M. FitzGerald
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Rebecca A. Clayton
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Jeannine D. Gocayne
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Anthony R. Kerlavage
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Brian A. Dougherty
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Jean-Francois Tomb
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Mark D. Adams
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Claudia I. Reich
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Ross Overbeek
    R. Overbeek is with the Division of Mathematics and Computer Science, Argonne National Laboratory, Argonne, IL 60439, USA.
  • Ewen F. Kirkness
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Keith G. Weinstock
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Joseph M. Merrick
    J. M. Merrick is in the Department of Microbiology, State University of New York, Buffalo, NY 14214, USA.
  • Anna Glodek
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • John L. Scott
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Neil S. M. Geoghagen
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Janice F. Weidman
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Joyce L. Fuhrmann
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Dave Nguyen
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Teresa R. Utterback
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Jenny M. Kelley
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Jeremy D. Peterson
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Paul W. Sadow
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Michael C. Hanna
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Matthew D. Cotton
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Kevin M. Roberts
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Margaret A. Hurst
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Brian P. Kaine
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Mark Borodovsky
    M. Borodovsky is with the School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
  • Hans-Peter Klenk
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Claire M. Fraser
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • Hamilton O. Smith
    H. O. Smith is in the Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. All other authors are with The Institute for Genomic Research (TIGR), Rockville, MD 20850, USA.
  • Carl R. Woese
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.
  • J. Craig Venter
    G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA.

抄録

<jats:p> The complete 1.66-megabase pair genome sequence of an autotrophic archaeon, <jats:italic>Methanococcus jannaschii</jats:italic> , and its 58- and 16-kilobase pair extrachromosomal elements have been determined by whole-genome random sequencing. A total of 1738 predicted protein-coding genes were identified; however, only a minority of these (38 percent) could be assigned a putative cellular role with high confidence. Although the majority of genes related to energy production, cell division, and metabolism in <jats:italic>M. jannaschii</jats:italic> are most similar to those found in Bacteria, most of the genes involved in transcription, translation, and replication in <jats:italic>M. jannaschii</jats:italic> are more similar to those found in Eukaryotes. </jats:p> <jats:p> <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="hbar" xlink:type="simple" /> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.jcvi.org/cms/research/projects/tdb/overview/" xlink:type="simple"> <jats:bold> The <jats:italic>Methanococcus jannaschii</jats:italic> Genome Database </jats:bold> </jats:ext-link> </jats:p>

収録刊行物

  • Science

    Science 273 (5278), 1058-1073, 1996-08-23

    American Association for the Advancement of Science (AAAS)

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